This course presents and summarises currently available knowledge on PK/PD of commonly used antibiotics, strategies for setting clinical breakpoints, individualised dosing and therapeutic drug monitoring. The aim is to provide participants with insights that can be used to optimise antibiotic therapy for different patient groups, infection sites and pathogens.
Infectious disease, ICU specialists from academia (or companies), clinical microbiologists, pharmacologists, pharmacists, who work or want to work in the field of antibacterial therapy.

Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

ESCMID PK/PD of Anti-Infectives Study Group - EPASG
The organizer(s) of the course will apply for European CME accreditation through EACCME.

Contact Person (Scientific Programme)

Markus Zeitlinger
Medical University of Vienna
Department of Clinical Pharmacology
Waehringer Guertel 18-20
1090 Vienna
+43 1 4040029810

Administrative Secretariat

Johan Mouton
Erasmus MC
Dept Med. Microbiol. Infect. Dis.
Postbus 2040
3000 CA Rotterdam
+31 10 703 3510

Venue Info

Event Map
Venue Details
Van der Valk Hotel Rotterdam-Blijdorp
Energieweg 2, 3041 JC Rotterdam

Thursday, 11 April 2019

08:15 - 08:30
Speaker(s): Johan Willem Mouton
Speaker(s): Roger L. Nation
Speaker(s): Ursula Theuretzbacher
08:30 - 08:35
Welcome and introduction
Speaker(s): Markus Zeitlinger
08:35 - 09:00
Why do we need to reconsider standard dosing regimens?
Speaker(s): Johan Willem Mouton
Speaker(s): Roger L. Nation
Speaker(s): Ursula Theuretzbacher
09:00 - 09:45
Basics of dosing (interactive) 
Speaker(s): Hartmut Derendorf
09:45 - 10:30
Dosing in special patient populations (interactive)
Speaker(s): Federico Pea
10:30 - 11:00
11:00 - 11:45
Current strategies for MIC determination and setting clinical breakpoints 
Speaker(s): Anouk Edwina Muller
11:45 - 12:15
Population PK modelling for individualised dosing
Speaker(s): Elisabet Nielsen
12:15 - 13:15
13:15 - 14:15
Preclinical infection models and what are experimental and clinical data supporting PK/PD targets?
Speaker(s): Brian Tsuji
14:15 - 15:00
Mathematical modelling of preclinical data to predict dosing strategies
Speaker(s): Lena Friberg
15:00 - 15:30
15:30 - 16:15
Optimal dosing and continuous or prolonged infusion of beta-lactams and vancomycin – what is the evidence?
Speaker(s): Jason Roberts
16:15 - 17:00
How to optimize the use of aminoglycosides, quinolones and polymyxins? (clinical case studies, interactive)
Speaker(s): Deborah Marriott

Friday, 12 April 2019

09:00 - 09:45
Impact of tissue penetration and when should local administration of antibiotics be considered? 
Speaker(s): Markus Zeitlinger
09:45 - 10:15
Principles of individualised dosing based on therapeutic drug monitoring 
Speaker(s): Roger Brüggemann
10:15 - 10:45
10:45 - 12:15
How to apply knowledge on PK/PD and TDM in clinical practice? (interactive, clinical cases and discussion)
Speaker(s): Angela Huttner
Speaker(s): Thomas Tängdén
12:15 - 13:30
13:30 - 14:30
A world with precision dosing and TDM  (pros and cons debate)
Speaker(s): Roger Brüggemann
Speaker(s): Jason Roberts
14:15 - 15:00
Future perspectives – clinical breakpoints and dosing in 20 years? 
Speaker(s): Johan Willem Mouton
15:00 - 15:30
15:30 - 16:00
Closing remarks and any remaining questions 
Speaker(s): Johan Willem Mouton
Speaker(s): Roger L. Nation
Speaker(s): Ursula Theuretzbacher

Accommodation (2 nights - Check-in 10 April, Check out 12 April), 4 coffee breaks, 2 lunches, 1 dinner.
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